通过 N-氯酰基-6-O-三苯甲基壳聚糖合成新型季铵化壳聚糖衍生物。
Synthesis of novel quaternary chitosan derivatives via N-Chloroacyl-6-O-triphenylmethylchitosans.
作者信息
Holappa Jukka, Nevalainen Tapio, Soininen Pasi, Másson Már, Järvinen Tomi
机构信息
Department of Pharmaceutical Chemistry, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland.
出版信息
Biomacromolecules. 2006 Feb;7(2):407-10. doi: 10.1021/bm050707j.
PMID:16471908
Abstract
Various quaternary chitosan derivative structures were synthesized by reacting N-chloroacyl-6-O-triphenylmethylchitosans with tertiary amines. Full substitutions were obtained from the quaternization reactions and the obtained water-soluble quaternary chitosan derivatives were thoroughly characterized with (1)H NMR, (13)C NMR, (1)H-(13)C HSQC NMR, and FT-IR.
摘要
通过使N-氯酰基-6-O-三苯甲基壳聚糖与叔胺反应，合成了各种季铵化壳聚糖衍生物结构。季铵化反应实现了完全取代，所得水溶性季铵化壳聚糖衍生物通过¹H NMR、¹³C NMR、¹H-¹³C HSQC NMR和傅里叶变换红外光谱（FT-IR）进行了全面表征。
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