用光靶向药物递送：一种高聚焦方法。
Targeting drug delivery with light: A highly focused approach.
机构信息
Department of Chemical Engineering, University of Washington, Seattle, WA 98105, USA.
Department of Chemical Engineering, University of Washington, Seattle, WA 98105, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA; Department of Chemistry, University of Washington, Seattle, WA 98105, USA; Institute of Stem Cell & Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Molecular Engineering & Sciences Institute, University of Washington, Seattle, WA 98105, USA.
出版信息
Adv Drug Deliv Rev. 2021 Apr;171:94-107. doi: 10.1016/j.addr.2021.01.009. Epub 2021 Jan 22.
Light is a uniquely powerful tool for controlling molecular events in biology. No other external input (e.g., heat, ultrasound, magnetic field) can be so tightly focused or so highly regulated as a clinical laser. Drug delivery vehicles that can be photonically activated have been developed across many platforms, from the simplest "caging" of therapeutics in a prodrug form, to more complex micelles and circulating liposomes that improve drug uptake and efficacy, to large-scale hydrogel platforms that can be used to protect and deliver macromolecular agents including full-length proteins. In this Review, we discuss recent innovations in photosensitive drug delivery and highlight future opportunities to engineer and exploit such light-responsive technologies in the clinical setting.
光是控制生物学中分子事件的独特有力工具。没有其他外部输入（例如热、超声、磁场）可以像临床激光那样如此紧密聚焦或高度调节。已经开发出了许多平台的光活化药物递送载体，从最简单的将治疗剂“笼状”在前药形式中，到更复杂的胶束和循环脂质体，以提高药物摄取和疗效，再到大规模水凝胶平台，可用于保护和递增大分子药物，包括全长蛋白质。在这篇综述中，我们讨论了光敏感药物递送的最新创新，并强调了未来在临床环境中设计和利用这种光响应技术的机会。
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