Huang Tiehua, Gao Ping, Hageman Michael J
Worldwide Pharmaceutical Sciences, Pfizer Inc., Kalamazoo, MI 49007, USA.
Curr Drug Discov Technol. 2004 Jun;1(2):173-9. doi: 10.2174/1570163043335117.
Cyclic voltammetry (CV) is a unique technique for the electrochemical characterization of compounds by providing their oxidation/reduction potentials. This technique is widely used in evaluating antioxidants in the oil, food, diagnostic and agricultural industries; however, CV is rarely used in the development of pharmaceutical formulations. This review briefly describes the basic principles of CV and its application in other industries along with the potential and limitations of CV in the rapid evaluation of antioxidants in pharmaceutical formulations. An extensive survey of the literature shows that there is a good correlation between the oxidation potentials of various antioxidants and their antioxidant efficiency. In conclusion, CV should be useful in the development of pharmaceutical formulations where a small group of the preferred antioxidants is rapidly identified. This small group of the most preferred antioxidants can then be employed in a conventional drug stability study thereby providing a rapid approach for the selection of the most suitable antioxidant for a pharmaceutical formulation.
循环伏安法（CV）是一种通过提供化合物的氧化/还原电位来对其进行电化学表征的独特技术。该技术广泛应用于石油、食品、诊断和农业等行业中抗氧化剂的评估；然而，循环伏安法在药物制剂开发中很少使用。本文综述简要介绍了循环伏安法的基本原理及其在其他行业中的应用，以及循环伏安法在快速评估药物制剂中抗氧化剂方面的潜力和局限性。对文献的广泛调查表明，各种抗氧化剂的氧化电位与其抗氧化效率之间存在良好的相关性。总之，循环伏安法在快速鉴定一小部分优选抗氧化剂的药物制剂开发中应会有用。然后可以将这一小部分最优选的抗氧化剂用于传统的药物稳定性研究，从而为选择最适合药物制剂的抗氧化剂提供一种快速方法。
