Saito K, Lackner A, Markey S P, Heyes M P
Section on Analytical Biochemistry, National Institute of Mental Health, Bethesda, MD 20892.
Brain Res. 1991 Feb 1;540(1-2):353-6. doi: 10.1016/0006-8993(91)90536-5.
Increased concentrations of the neuroactive kynurenine pathway metabolites, quinolinic acid (QUIN) and kynurenic acid (KYNA), occur in the CSF of humans infected with the human immunodeficiency virus and macaques infected with retroviruses, including the D/1/California serotype. In the present study, increased activity of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, occurred in cerebral cortex and lung of macaques with clinical SAIDS. Such increases provide a mechanism to accelerate the formation of kynurenine pathway metabolites in both systemic tissues and the central nervous system.
在感染人类免疫缺陷病毒的人类以及感染包括D/1/加利福尼亚血清型在内的逆转录病毒的猕猴的脑脊液中，神经活性犬尿氨酸途径代谢产物喹啉酸（QUIN）和犬尿喹啉酸（KYNA）的浓度会升高。在本研究中，患有临床猴艾滋病的猕猴的大脑皮层和肺中，犬尿氨酸途径的首个酶——吲哚胺-2,3-双加氧酶（IDO）的活性增强。这种增强为全身组织和中枢神经系统中犬尿氨酸途径代谢产物的加速形成提供了一种机制。
