Saito K, Markey S P, Heyes M P
Section on Analytical Biochemistry, National Institute of Mental Health, Bethesda, MD 20892.
Brain Res. 1991 Apr 12;546(1):151-4. doi: 10.1016/0006-8993(91)91171-v.
Chronic infections are associated with increased concentrations of the neuroactive kynurenine pathway metabolite, quinolinic acid (QUIN), in blood and cerebrospinal fluid. In the present study, repeated injections of gamma-interferon (5000 IU, every 3 days for 39 days) to C57BL6 mice were associated with persistent activation of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, in lung and brain, sustained increases in brain QUIN concentration and increases in plasma L-kynurenine and QUIN levels. Mice chronically treated with gamma-interferon offer an animal model to investigate the effects of sustained immune stimulation on kynurenine pathway metabolism.
慢性感染与血液和脑脊液中神经活性犬尿氨酸途径代谢产物喹啉酸（QUIN）浓度升高有关。在本研究中，对C57BL6小鼠反复注射γ-干扰素（5000国际单位，每3天一次，共39天）与肺和脑中犬尿氨酸途径的首个酶——吲哚胺-2,3-双加氧酶（IDO）的持续激活、脑QUIN浓度的持续升高以及血浆L-犬尿氨酸和QUIN水平的升高有关。长期接受γ-干扰素治疗的小鼠为研究持续免疫刺激对犬尿氨酸途径代谢的影响提供了一个动物模型。
