de Jonge Maja J A, Verweij Jaap
Department of Medical Oncology, Erasmus Medical Center/Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
Semin Oncol. 2006 Feb;33(1):68-73. doi: 10.1053/j.seminoncol.2005.11.011.
Chemotherapeutic agents can produce a variety of acute and chronic organ toxicities. Since many antitumor drugs and their metabolites are cleared renally, the kidneys are vulnerable to injury. The drugs involved will determine the site of injury within the kidney, resulting in clinical manifestations ranging from an asymptomatic rise in serum creatinine to acute renal failure. The most common renal toxicities of chemotherapeutic agents are described.
化疗药物可产生多种急慢性器官毒性。由于许多抗肿瘤药物及其代谢产物经肾脏清除，肾脏易受损伤。所涉及的药物将决定肾脏内的损伤部位，导致从血清肌酐无症状升高到急性肾衰竭等一系列临床表现。本文描述了化疗药物最常见的肾毒性。
