Camacho Javier
Pharmacology Section, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Avenida Instituto Politécnico Nacional 2508, México, DF 07360, México.
Cancer Lett. 2006 Feb 20;233(1):1-9. doi: 10.1016/j.canlet.2005.02.016.
Ion channels play important roles in health and disease. In the last few years, an interesting relationship between potassium channels and cancer has evolved. Especially, members of the ether à go-go (EAG) potassium channels family have gained interest as research tools for detection and therapy of different cancers. This review will summarize most of the findings relating EAG channels and cancer, focusing on mRNA expression in tissues, oncogenic properties, modulation and pharmacology. Plausible scenarios on the cellular mechanisms of EAG oncogenicity will be discussed.
离子通道在健康和疾病中发挥着重要作用。在过去几年中，钾通道与癌症之间演化出了一种有趣的关系。特别是，超极化激活环核苷酸门控（EAG）钾通道家族成员作为不同癌症检测和治疗的研究工具受到了关注。本综述将总结与EAG通道和癌症相关的大部分研究结果，重点关注组织中的mRNA表达、致癌特性、调节和药理学。还将讨论EAG致癌性细胞机制的合理设想。
