动脉粥样硬化与凝集素样氧化型低密度脂蛋白清除受体
Atherosclerosis and the Lectin-like OXidized low-density lipoprotein scavenger receptor.
作者信息
Vohra Ravinder S, Murphy Jane E, Walker John H, Ponnambalam Sreenivasan, Homer-Vanniasinkam Shervanthi
机构信息
Leeds Vascular Institute, The General Infirmary at Leeds, Great George Street, Leeds LS1 3EX, UK.
出版信息
Trends Cardiovasc Med. 2006 Feb;16(2):60-4. doi: 10.1016/j.tcm.2005.12.001.
The Lectin-like OXidized low-density lipoprotein scavenger receptor (LOX-1) is implicated in vascular inflammation and atherosclerotic plaque initiation, progression, and destabilization. LOX-1 levels are elevated upon recognition of oxidized low-density lipoprotein, a key pro-atherogenic substance in the vasculature. Recent evidence indicates this gene product is a biomarker of inflammation and disease status. We review and assess the role of LOX-1 in atherosclerotic plaque formation, physiologic regulation, and as a biomarker and target in cardiovascular disease diagnosis and prevention.
凝集素样氧化型低密度脂蛋白清道夫受体（LOX-1）与血管炎症以及动脉粥样硬化斑块的起始、进展和不稳定有关。在识别氧化型低密度脂蛋白（血管中一种关键的促动脉粥样硬化物质）后，LOX-1水平会升高。最近的证据表明，这种基因产物是炎症和疾病状态的生物标志物。我们综述并评估了LOX-1在动脉粥样硬化斑块形成、生理调节中的作用，以及作为心血管疾病诊断和预防中的生物标志物和靶点的作用。
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