Mosimann Urs P, Rowan Elise N, Partington Cassie E, Collerton Daniel, Littlewood Elizabeth, O'Brien John T, Burn David J, McKeith Ian G
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom.
Am J Geriatr Psychiatry. 2006 Feb;14(2):153-60. doi: 10.1097/01.JGP.0000192480.89813.80.
Parkinson disease dementia (PDD) and dementia with Lewy bodies (DLB) have overlapping clinical and pathologic features. Recurrent visual hallucinations (RVH) are common in both disorders. The authors have compared details of hallucination characteristics and associated neuropsychiatric features in DLB and PDD.
This is a descriptive, cross-sectional study using the Institute of Psychiatry Visual Hallucinations Interview (IP-VHI) to explore self-reported frequency, duration, and phenomenology of RVH in PDD and DLB. The caregivers' ratings of hallucinations and other neuropsychiatric features were elicited with the Neuropsychiatric Inventory (NPI).
Fifty-six patients (35 PDD; 21 DLB) with RVH were assessed. Hallucination characteristics were similar in both disorders. Simple hallucinations were rare. Most patients experienced complex hallucinations daily, normally lasting minutes. They commonly saw people or animals and the experiences were usually perceived as unpleasant. NPI anxiety scores were higher in PDD. Neuropsychiatric symptoms coexisting with hallucinations were apathy, sleep disturbance, and anxiety.
Patients with mild to moderate dementia can provide detailed information about their hallucinations. Characteristics of RVH were similar in PDD and DLB, and phenomenology suggests the involvement of dorsal and ventral visual pathways in their generation. The coexistence of RVH with anxiety, apathy, and sleep disturbance is likely to impair patients' quality of life and may have treatment implications.
帕金森病痴呆（PDD）和路易体痴呆（DLB）具有重叠的临床和病理特征。反复出现的视幻觉（RVH）在这两种疾病中都很常见。作者比较了DLB和PDD中幻觉特征及相关神经精神特征的细节。
这是一项描述性横断面研究，使用精神病学研究所视幻觉访谈（IP-VHI）来探究PDD和DLB中自我报告的RVH频率、持续时间和现象学。通过神经精神科问卷（NPI）得出照顾者对幻觉及其他神经精神特征的评分。
对56例有RVH的患者（35例PDD；21例DLB）进行了评估。两种疾病的幻觉特征相似。简单幻觉很少见。大多数患者每天都会经历复杂幻觉，通常持续数分钟。他们常见到人和动物，且这些体验通常被认为是不愉快的。PDD患者的NPI焦虑评分更高。与幻觉共存的神经精神症状有冷漠、睡眠障碍和焦虑。
轻至中度痴呆患者能够提供有关其幻觉的详细信息。PDD和DLB中RVH的特征相似，且现象学表明其产生涉及背侧和腹侧视觉通路。RVH与焦虑、冷漠和睡眠障碍共存可能会损害患者的生活质量，并且可能对治疗有影响。
