Ayalon Liat, Ancoli-Israel Sonia, Stepnowsky Carl, Marler Matthew, Palmer Barton W, Liu Lianqi, Loredo Jose S, Corey-Bloom Jody, Greenfield Deborah, Cooke Jana
Department of Psychiatry, University of California, San Diego, San Diego, CA, and Veterans Affairs San Diego Health Care System, San Diego, CA 92161, USA.
Am J Geriatr Psychiatry. 2006 Feb;14(2):176-80. doi: 10.1097/01.JGP.0000192484.12684.cd.
This analysis examined whether patients with Alzheimer disease (AD) tolerate continuous positive airway pressure (CPAP).
Thirty patients with AD were randomized to CPAP or sham CPAP and completed sleep, depression, and quality-of-life questionnaires. Participants could choose to continue treatment after the trial.
Patients wore CPAP for 4.8 hours per night. More depressive symptoms were associated with worse adherence (rS=-0.37; N=30, p<0.04). Patients who continued using CPAP had fewer depressive symptoms (t [19]=2.45, p=0.02) and better adherence (t [19]=2.32, p=0.03) during the trial.
Patients with AD with obstructive sleep apnea can tolerate CPAP. Adherence and long-term use may be more difficult among those patients with more depressive symptoms.
本分析旨在研究阿尔茨海默病（AD）患者对持续气道正压通气（CPAP）的耐受性。
30例AD患者被随机分为CPAP组或假CPAP组，并完成睡眠、抑郁和生活质量问卷。试验结束后，参与者可选择继续治疗。
患者每晚使用CPAP的时间为4.8小时。抑郁症状越严重，依从性越差（斯皮尔曼相关系数rS=-0.37；N=30，p<0.04）。在试验期间，继续使用CPAP的患者抑郁症状较少（t[19]=2.45，p=0.02），依从性更好（t[19]=2.32，p=0.03）。
患有阻塞性睡眠呼吸暂停的AD患者能够耐受CPAP。抑郁症状较多的患者在坚持使用和长期使用方面可能会更困难。
