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在正确的时间出现在正确的地点。

Being in the right place at the right time.

作者信息

Ancoli-Israel Sonia

机构信息

Department of Psychiatry, University of California, San Diego, CA, United States.

出版信息

Sleep Adv. 2025 May 21;6(2):zpaf033. doi: 10.1093/sleepadvances/zpaf033. eCollection 2025 Apr.

DOI:10.1093/sleepadvances/zpaf033
PMID:40575623
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12199614/
Abstract

This paper is a review of my life as a sleep researcher and clinician. I chanced into sleep by being at the right place at the right time. Over the last 45 years, I became an expert on sleep and circadian rhythms in aging, in Alzheimer's disease and Parkinson's disease and in cancer. We were one of the first to show how common sleep apnea and periodic limb movements in sleep are in the elderly. We "moved" into the nursing home and showed how disrupted sleep is in these patients. We used light therapy to improve sleep in the nursing home. We studied the effect of CPAP on sleep and cognition in both Alzheimer's disease and Parkinson's disease. And we were some of the first to study sleep and circadian rhythms in women with breast cancer, starting the evaluations before they started their chemotherapy. These studies were both observational and treatment studies. I am very proud of the work we did. For me, everything revolves around sleep. And that is the beginning of my story.

摘要

本文回顾了我作为一名睡眠研究员和临床医生的职业生涯。我在恰当的时间身处恰当的地点，从而偶然进入了睡眠研究领域。在过去的45年里，我成为了衰老、阿尔茨海默病、帕金森病以及癌症领域中睡眠和昼夜节律方面的专家。我们是最早一批揭示睡眠呼吸暂停和睡眠中周期性肢体运动在老年人中多么常见的人之一。我们走进养老院，展示了这些患者的睡眠是多么紊乱。我们使用光疗法改善养老院患者的睡眠。我们研究了持续气道正压通气（CPAP）对阿尔茨海默病和帕金森病患者睡眠及认知的影响。并且我们是最早一批研究乳腺癌女性的睡眠和昼夜节律的人，在她们开始化疗之前就展开了评估。这些研究既有观察性研究，也有治疗性研究。我为我们所做的工作深感自豪。对我来说，一切都围绕着睡眠展开。而这就是我的故事的开端。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/edbdf8083fb6/zpaf033_fig21.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/0a6b3f2d596c/zpaf033_fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/edbdf8083fb6/zpaf033_fig21.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/0a6b3f2d596c/zpaf033_fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/f9b45fd263e6/zpaf033_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/42cad0a2d85e/zpaf033_fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/ee1179c70cf8/zpaf033_fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/57fe4a7cd005/zpaf033_fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/7afa24396a34/zpaf033_fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/102048aa004f/zpaf033_fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/daa98270021a/zpaf033_fig13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/646457b6094c/zpaf033_fig14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/0e7b207ce859/zpaf033_fig15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/da436ce91be7/zpaf033_fig16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/831b5df7d44a/zpaf033_fig17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/fa4fe9ba5082/zpaf033_fig18.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/a40c47cdbeaa/zpaf033_fig19.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/195c/12199614/edbdf8083fb6/zpaf033_fig21.jpg

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本文引用的文献

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Reductions in sleep quality and circadian activity rhythmicity predict longitudinal changes in objective and subjective cognitive functioning in women treated for breast cancer.睡眠质量和昼夜活动节律的下降可预测接受乳腺癌治疗的女性的客观和主观认知功能的纵向变化。
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Prevention of quality-of-life deterioration with light therapy is associated with changes in fatigue in women with breast cancer undergoing chemotherapy.
光疗预防生活质量下降与接受化疗的乳腺癌女性的疲劳变化有关。
Qual Life Res. 2013 Aug;22(6):1239-44. doi: 10.1007/s11136-012-0243-2. Epub 2012 Aug 3.
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Bright light therapy protects women from circadian rhythm desynchronization during chemotherapy for breast cancer.光照疗法可保护女性在乳腺癌化疗期间免受昼夜节律失调的影响。
Behav Sleep Med. 2012;10(3):202-16. doi: 10.1080/15402002.2011.634940.
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Light treatment prevents fatigue in women undergoing chemotherapy for breast cancer.光照疗法可预防乳腺癌化疗女性的疲劳。
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Sustained use of CPAP slows deterioration of cognition, sleep, and mood in patients with Alzheimer's disease and obstructive sleep apnea: a preliminary study.持续使用 CPAP 可减缓阿尔茨海默病合并阻塞性睡眠呼吸暂停患者的认知、睡眠和情绪恶化：一项初步研究。
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Breast cancer patients have progressively impaired sleep-wake activity rhythms during chemotherapy.乳腺癌患者在化疗期间的睡眠-觉醒活动节律会逐渐受损。
Sleep. 2009 Sep;32(9):1155-60. doi: 10.1093/sleep/32.9.1155.
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Continuous positive airway pressure deepens sleep in patients with Alzheimer's disease and obstructive sleep apnea.持续气道正压通气可加深阿尔茨海默病合并阻塞性睡眠呼吸暂停患者的睡眠。
Sleep Med. 2009 Dec;10(10):1101-6. doi: 10.1016/j.sleep.2008.12.016. Epub 2009 Aug 20.
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Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study.治疗阿尔茨海默病阻塞性睡眠呼吸暂停的认知效应：一项随机对照研究。
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Pre-treatment symptom cluster in breast cancer patients is associated with worse sleep, fatigue and depression during chemotherapy.乳腺癌患者的治疗前症状群与化疗期间更严重的睡眠、疲劳和抑郁相关。
Psychooncology. 2009 Feb;18(2):187-94. doi: 10.1002/pon.1412.