精氨酸酶缺乏症基因替代治疗试验失败。
Unsuccessful trial of gene replacement in arginase deficiency.
作者信息
Terheggen H G, Lowenthal A, Lavinha F, Colombo J P, Rogers S
出版信息
Z Kinderheilkd. 1975;119(1):1-3. doi: 10.1007/BF00464689.
PMID:164740
Abstract
The Shope virus following cutaneous inoculation produces skin papillomas in rabbits and induces a virus-coded arginase in the squameous epithelium of these papillomas. The only discernible effect of the virus inoculated intravenously in rabbits and other animals was a decrease of the serum arginine concentration. Intravenous injection in 3 hyperargininemic patients, however, did not influence the underlying metabolic disease.
摘要
肖普病毒经皮肤接种后可在兔身上产生皮肤乳头瘤，并在这些乳头瘤的鳞状上皮中诱导一种病毒编码的精氨酸酶。然而，将该病毒静脉注射到兔和其他动物体内后，唯一可察觉到的影响是血清精氨酸浓度降低。不过，对3名高精氨酸血症患者进行静脉注射并未影响其潜在的代谢疾病。
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