Bürk Katrin, Daum Irene, Rüb Udo
Department of Neurology, University of Ulm, Ulm, and Department of Neurology, University of Tübingen, Tübingen, Germany.
Mov Disord. 2006 Jun;21(6):772-6. doi: 10.1002/mds.20802.
Dementia represents an exclusion criterion for the diagnosis of multiple system atrophy (MSA), but there have been reports of fronto-executive dysfunction in patients with MSA of the striatonigral type (MSA-P). To study the cognitive profile of MSA, 20 patients with MSA of the cerebellar type (MSA-C) were subjected to an extensive neuropsychological test battery comprising tests for IQ, attention, verbal and visuospatial memory, as well as executive function. There was evidence for impaired verbal memory and verbal fluency. Test performance was not related to the severity of motor disability. Regarding the similar cognitive syndrome of MSA-P, the otherwise subclinical problems in MSA-C result from subcortical rather than from cerebellar dysfunction.
痴呆是多系统萎缩（MSA）诊断的排除标准，但已有报告称纹状体黑质型（MSA-P）MSA患者存在额叶执行功能障碍。为研究MSA的认知特征，对20例小脑型（MSA-C）MSA患者进行了广泛的神经心理测试组合，包括智商、注意力、言语和视觉空间记忆以及执行功能测试。有证据表明言语记忆和言语流畅性受损。测试表现与运动残疾的严重程度无关。关于MSA-P的类似认知综合征，MSA-C中原本亚临床的问题是由皮质下功能障碍而非小脑功能障碍导致的。
