[支气管哮喘患者血浆与淋巴细胞中环磷酸腺苷含量的比值]
[The ratio of the cAMP content of the plasma and lymphocytes in bronchial asthma patients].
作者信息
Diban G
出版信息
Vrach Delo. 1991 Feb(2):74-6.
PMID:1647569
Abstract
The author revealed a reduction of cAMP in the blood plasma and lymphocytes in patients with a severe course of infection-dependent bronchial asthma during exacerbation of the disease. Continuing use of glucocorticoid hormones (hormone-dependent asthma) is accompanied by normalization of cAMP values. It is suggested that glucocorticoids produce a stimulating effect on nucleotide synthesis. It is also not excluded that there is also another mechanism of cAMP increase, namely anti-phosphodiesterase effect of glucocorticoids.
摘要
作者发现，在感染依赖性支气管哮喘重症患者疾病加重期，其血浆和淋巴细胞中的环磷酸腺苷（cAMP）水平降低。持续使用糖皮质激素（激素依赖性哮喘）会使cAMP值恢复正常。提示糖皮质激素对核苷酸合成有刺激作用。也不排除存在cAMP增加的另一种机制，即糖皮质激素的抗磷酸二酯酶作用。
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