适用于评估对水痘活疫苗免疫反应的抗体检测方法。
Antibody assays suitable for assessing immune responses to live varicella vaccine.
作者信息
Provost P J, Krah D L, Kuter B J, Morton D H, Schofield T L, Wasmuth E H, White C J, Miller W J, Ellis R W
机构信息
Cellular and Molecular Biology, Merck Sharp & Dohme Research Laboratories, West Point, PA 19486.
出版信息
Vaccine. 1991 Feb;9(2):111-6. doi: 10.1016/0264-410x(91)90266-9.
An enzyme-linked immunosorbent assay for antibodies to varicella-zoster virus (VZV), using purified viral glycoproteins as antigen (gpELISA), was compared with other assays for measuring vaccine-induced antibody responses. The gpELISA was more sensitive than conventional assays, proved highly specific for VZV and agreed well with an assay for neutralizing antibody activity. It was successfully applied to large-scale testing of live varicella vaccine in humans.
一种以纯化病毒糖蛋白为抗原的酶联免疫吸附测定法检测水痘-带状疱疹病毒（VZV）抗体（gpELISA），与其他用于测量疫苗诱导抗体反应的检测方法进行了比较。gpELISA比传统检测方法更敏感，对VZV具有高度特异性，并且与中和抗体活性检测结果高度一致。它已成功应用于人类水痘活疫苗的大规模检测。
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