Samia Anna C S, Dayal Smita, Burda Clemens
Center for Chemical Dynamics and Nanomaterials Research, Department of Chemistry, Case Western Reserve University, Cleveland, OH, USA.
Photochem Photobiol. 2006 May-Jun;82(3):617-25. doi: 10.1562/2005-05-11-IR-525.
Quantum dots have emerged as an important class of material that offers great promise to a diverse range of applications ranging from energy conversion to biomedicine. Here, we review the potential of using quantum dots and quantum dot conjugates as sensitizers for photodynamic therapy (PDT). The photophysics of singlet oxygen generation in relation to quantum dot-based energy transfer is discussed and the possibility of using quantum dots as photosensitizer in PDT is assessed, including their current limitations to applications in biological systems. The biggest advantage of quantum dots over molecular photosensitizers that comes into perspective is their tunable optical properties and surface chemistries. Recent developments in the preparation and photophysical characterization of quantum dot energy transfer processes are also presented in this review, to provide insights on the future direction of quantum dot-based photosensitization studies from the viewpoint of our ongoing research.
量子点已成为一类重要的材料，在从能量转换到生物医学等各种应用中展现出巨大潜力。在此，我们综述了将量子点及量子点共轭物用作光动力疗法（PDT）敏化剂的潜力。讨论了与基于量子点的能量转移相关的单线态氧产生的光物理过程，并评估了在光动力疗法中使用量子点作为光敏剂的可能性，包括其目前在生物系统应用中的局限性。量子点相对于分子光敏剂最显著的优势在于其可调谐的光学性质和表面化学性质。本综述还介绍了量子点能量转移过程制备和光物理表征方面的最新进展，以便从我们正在进行的研究角度为基于量子点的光敏化研究的未来方向提供见解。
