Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
Biosensor Sciences and Technologies Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
Anticancer Agents Med Chem. 2024;24(10):733-744. doi: 10.2174/0118715206295598240215112910.
Semiconductor quantum dots (QD) are a kind of nanoparticle with unique optical properties that have attracted a lot of attention in recent years. In this paper, the characteristics of these nanoparticles and their applications in nanophototherapy have been reviewed. Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), has gained special importance because of its high accuracy and local treatment due to the activation of the drug at the tumor site. PDT is a new way of cancer treatment that is performed by activating light-sensitive compounds named photosensitizers (PS) by light. PSs cause the destruction of diseased tissue through the production of singlet oxygen. PTT is another non-invasive method that induces cell death through the conversion of near-infrared light (NIR) into heat in the tumor situation by the photothermal agent (PA). Through using energy transfer the FRET (Förster resonance energy transfer) process, QDs provide light absorption wavelength for both methods and cover the optical weaknesses of phototherapy agents.
半导体量子点 (QD) 是一种具有独特光学性质的纳米粒子，近年来引起了广泛关注。本文综述了这些纳米粒子的特性及其在纳米光疗中的应用。光疗，包括光动力疗法 (PDT) 和光热疗法 (PTT)，由于药物在肿瘤部位的激活而具有高精度和局部治疗的特点，因此受到特别重视。PDT 是一种新的癌症治疗方法，通过激活光敏化合物（称为光敏剂 (PS)）来进行。PS 通过产生单线态氧来破坏病变组织。PTT 是另一种非侵入性方法，通过光热剂 (PA) 将近红外光 (NIR) 在肿瘤情况下转化为热，从而诱导细胞死亡。通过使用能量转移，FRET（Förster 共振能量转移）过程为这两种方法提供了光吸收波长，并弥补了光疗剂的光学弱点。
