Dean Brian, Gray Laura, Scarr Elizabeth
The Rebecca L. Cooper Research Laboratories, The Mental Health Research Institute of Victoria, The University of Melbourne, Parkville, Victoria, Australia.
Aust N Z J Psychiatry. 2006 Mar;40(3):217-24. doi: 10.1080/j.1440-1614.2006.01777.x.
To determine if levels of the glial-derived proteins S100beta and glial acidic fibrillary protein (GFAP) and the pro- and antiapoptotic proteins p53 and Bcl-2 were altered in the cortex of subjects with schizophrenia or bipolar 1 disorder.
Levels of S100beta, GFAP, p53 and Bcl-2 were measured in cortex (Brodmann's Areas (BAs) 9, 10, 46 and 40) of control subjects and subjects with schizophrenia, bipolar 1 disorder and in the cortex of rats treated with haloperidol or lithium using protein-specific antibodies and western blot analysis.
Levels of S100beta were decreased in BA 9 and increased in BA 40 from subjects with bipolar 1 disorder. Levels of this protein were not altered in other CNS regions, in schizophrenia or in the cortex of rats treated with haloperidol or lithium. No changes in levels of the other three proteins were detected across diagnoses.
Regionally selective changes in cortical S100beta may be associated with the pathology of bipolar 1 disorder and may reflect derangements in neuronal death or survival.
确定在精神分裂症或双相I型障碍患者的大脑皮层中，神经胶质源性蛋白S100β和胶质酸性纤维蛋白（GFAP）以及促凋亡蛋白和抗凋亡蛋白p53和Bcl-2的水平是否发生改变。
使用蛋白特异性抗体和蛋白质印迹分析，测量对照受试者、精神分裂症患者、双相I型障碍患者大脑皮层（布罗德曼区（BAs）9、10、46和40）以及用氟哌啶醇或锂治疗的大鼠大脑皮层中S100β、GFAP、p53和Bcl-2的水平。
双相I型障碍患者的BA 9区中S100β水平降低，BA 40区中S100β水平升高。在其他中枢神经系统区域、精神分裂症患者或用氟哌啶醇或锂治疗的大鼠大脑皮层中，该蛋白水平未发生改变。在所有诊断组中均未检测到其他三种蛋白水平的变化。
大脑皮层S100β的区域选择性变化可能与双相I型障碍的病理过程有关，并且可能反映神经元死亡或存活的紊乱。
