中枢神经系统疾病和情绪障碍中的类淋巴系统功能障碍
Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders.
作者信息
Zhang Dianjun, Li Xinyu, Li Baoman
机构信息
Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China.
Liaoning Province Key Laboratory of Forensic Bio-evidence Sciences, School of Forensic Medicine, China Medical University, Shenyang, China.
出版信息
Front Aging Neurosci. 2022 Apr 25;14:873697. doi: 10.3389/fnagi.2022.873697. eCollection 2022.
The glymphatic system, a recently discovered macroscopic waste removal system in the brain, has many unknown aspects, especially its driving forces and relationship with sleep, and thus further explorations of the relationship between the glymphatic system and a variety of possible related diseases are urgently needed. Here, we focus on the progress in current research on the role of the glymphatic system in several common central nervous system diseases and mood disorders, discuss the structural and functional abnormalities of the glymphatic system which may occur before or during the pathophysiological progress and the possible underlying mechanisms. We emphasize the relationship between sleep and the glymphatic system under pathological conditions and summarize the common imaging techniques for the glymphatic system currently available. The perfection of the glymphatic system hypothesis and the exploration of the effects of aging and endocrine factors on the central and peripheral regulatory pathways through the glymphatic system still require exploration in the future.
胶质淋巴系统是大脑中最近发现的一种宏观废物清除系统，有许多未知方面，尤其是其驱动力以及与睡眠的关系，因此迫切需要进一步探索胶质淋巴系统与各种可能相关疾病之间的关系。在此，我们重点关注胶质淋巴系统在几种常见中枢神经系统疾病和情绪障碍中作用的当前研究进展，讨论胶质淋巴系统在病理生理进展之前或期间可能出现的结构和功能异常以及潜在机制。我们强调病理条件下睡眠与胶质淋巴系统之间的关系，并总结目前可用的胶质淋巴系统常见成像技术。胶质淋巴系统假说的完善以及通过胶质淋巴系统对衰老和内分泌因素对中枢和外周调节途径影响的探索在未来仍有待探索。
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