Black S B, Cherry J D, Shinefield H R, Fireman B, Christenson P, Lampert D
Northern California Kaiser Permanente Vaccine Study Center, Oakland 94611.
Am J Dis Child. 1991 Jul;145(7):746-9.
To investigate the possibility that there might be an increased risk of heterologous invasive bacterial disease after routine childhood immunization with measles, mumps, and rubella vaccine live; diphtheria and tetanus toxoids and pertussis vaccine; and oral poliovirus vaccine live, a case-control study was conducted within the Kaiser Permanente Northern California pediatric population. Contrary to the premise, an apparent protective effect against invasive bacterial disease was detected after all childhood vaccinations. However, when adjustment was made for frequency of well-care visits and day-care attendance, no significant relationship was seen between receipt of routine childhood immunizations and risk of invasive heterologous bacterial disease for any individual vaccine, although a statistically significant protective effect was detected within 1 or 3 months after the receipt of any vaccine. Since a decreased risk of invasive bacterial disease was also noted to be related to the receipt of routine well-child pediatric care, other preventive health care measures may be responsible for the apparent immunization protective effect.
为了调查在儿童常规接种麻疹、腮腺炎和风疹减毒活疫苗、白喉和破伤风类毒素及百日咳疫苗以及口服脊髓灰质炎减毒活疫苗后，发生异源性侵袭性细菌疾病的风险是否可能增加，在北加利福尼亚州凯撒医疗集团的儿科人群中开展了一项病例对照研究。与前提相反，在所有儿童疫苗接种后均检测到对侵袭性细菌疾病有明显的保护作用。然而，在对健康检查就诊频率和日托出勤情况进行调整后，对于任何一种疫苗而言，儿童常规免疫接种与侵袭性异源性细菌疾病风险之间均未发现显著关联，尽管在接种任何疫苗后的1或3个月内检测到了具有统计学意义的保护作用。由于侵袭性细菌疾病风险降低也被认为与儿童常规健康护理的接受情况有关，其他预防性医疗保健措施可能是这种明显的免疫保护作用的原因。
