Balabanli Barbaros, Türközkan Nurten, Balabanli Sema, Erdamar Husamettin, Akmansu Müge
Department of Biochemistry, Faculty of Science and Art, Gazi University, Ankara, Turkey.
Mol Cell Biochem. 2006 Jun;286(1-2):103-5. doi: 10.1007/s11010-005-9099-x. Epub 2006 Feb 14.
The aim of this investigation was to determine whether pre-administration of vitamin A will be effective in preventing the radiation-induced decline in MPO-H2O2 system and the end product of reactive nitrogen species (NOx) in guinea pig. Animals were subjected to 612 cG of radiation and polimorfonuclear leukocytes were isolated and then NOx and myeloperoxidase activity were measured. In irradiated animals, a marked decrease in NOx level and myeloperoxidase activity have been found compared to control (p = 0.001 and p < 0.000 respectively). The application of vitamin A significantly improved the radiation-induced decrease (for both p < 0.00). In conclusion pre-treatment of vitamin A is efficient to protect against radiation induced alteration in polimorfonuclear leukocyte.
本研究的目的是确定预先给予维生素A是否能有效预防豚鼠辐射诱导的MPO-H2O2系统下降以及活性氮物质（NOx）终产物的变化。对动物进行612 cG的辐射，分离出多形核白细胞，然后测量NOx和髓过氧化物酶活性。与对照组相比，辐照动物的NOx水平和髓过氧化物酶活性显著降低（分别为p = 0.001和p < 0.000）。维生素A的应用显著改善了辐射诱导的下降（两者p < 0.00）。总之，维生素A预处理可有效预防辐射诱导的多形核白细胞改变。
