Department of Psychology, University of Campania "Luigi Vanvitelli", Caserta, Italy.
Department of Neurology and Laboratory of Neuroscience, IRCCS, Istituto Auxologico Italiano, Milano, Italy.
Neurol Sci. 2023 May;44(5):1607-1612. doi: 10.1007/s10072-023-06619-w. Epub 2023 Jan 18.
Depression is one of the most disabling neuropsychiatric manifestations of Parkinson's disease (PD) and requires proper screening and diagnosis because it affects the overall prognosis and quality of life of patients. This study aimed to assess the psychometric and diagnostic properties of the Beck Depression Inventory-II (BDI-II) in an Italian PD cohort.
Fifty consecutive outpatients with PD underwent the Italian version of the BDI-II and other questionnaires to evaluate anxiety and apathetic symptoms. Patients' caregivers completed the depression/dysphoria domain of the Neuropsychiatric Inventory (NPI-D). We evaluated the internal consistency, convergent and divergent validity, and factorial structure of BDI-II. Sensitivity, specificity, positive and negative predictive values, and likelihood ratios were computed using ROC analyses, and an optimal cutoff was defined using the Youden index.
The BDI-II proved to be internally consistent (Cronbach's α = 0.840) and substantially met the bi-factorial structure. Regarding construct validity, the BDI-II was substantially related to anxiety measures, but not to apathy. With the combination of the NPI-D and anxiety score used as the gold standard, the BDI-II overall showed good accuracy (AUC = 0.859) with adequate sensitivity (75%) and specificity (87%). The optimal cutoff point was defined at 14.50.
We provide evidence of the psychometric and diagnostic properties of the Italian version of the BDI-II as a screening tool for depression in patients with PD. The BDI-II was found to be reliable and valid for the measurement of depression in patients with PD; therefore, it is available for use in clinical research and practice.
抑郁症是帕金森病（PD）最具致残性的神经精神表现之一，需要进行适当的筛查和诊断，因为它会影响患者的整体预后和生活质量。本研究旨在评估贝克抑郁量表第二版（BDI-II）在意大利 PD 患者中的心理测量和诊断特性。
50 名连续的 PD 门诊患者接受了意大利版 BDI-II 及其他评估焦虑和淡漠症状的问卷。患者的护理人员完成了神经精神疾病问卷（NPI-D）的抑郁/烦躁不安域。我们评估了 BDI-II 的内部一致性、收敛和发散效度以及因子结构。使用 ROC 分析计算了 BDI-II 的敏感性、特异性、阳性和阴性预测值以及似然比，并使用 Youden 指数定义了最佳截断值。
BDI-II 表现出较好的内部一致性（Cronbach's α=0.840），并在很大程度上符合双因素结构。关于构念效度，BDI-II 与焦虑测量指标有显著关联，但与淡漠无关。结合 NPI-D 和焦虑评分作为金标准，BDI-II 总体具有较好的准确性（AUC=0.859），灵敏度（75%）和特异性（87%）适中。最佳截断值定义为 14.50。
我们提供了意大利版 BDI-II 作为 PD 患者抑郁筛查工具的心理测量和诊断特性的证据。BDI-II 被发现是可靠和有效的，可用于测量 PD 患者的抑郁；因此，它可用于临床研究和实践。
