van Amsterdam Jan, van der Horst-Graat Judith, Bischoff Erik, Steerenberg Peter, Opperhuizen Antoon, Schouten Evert
Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Int J Vitam Nutr Res. 2005 Sep;75(5):327-31. doi: 10.1024/0300-9831.75.5.327.
Contradictory results have been published on the immune-stimulating effects of vitamin E. Using a randomized placebo-controlled design, the effect of 15 month's daily supplementation with 200 mg vitamin E on two biomarkers of immunocompetence, i.e. serum DHEA sulfate ester (DHEA-S) and neopterin, was studied. Of the 100 relatively healthy Dutch elderly subjects included in the study, 50 were supplemented with vitamin E and 50 received placebo. As compared to placebo, vitamin E supplementation affected neither serum DHEA-S nor serum neopterin level. This corroborates with the finding that vitamin E supplementation did not affect infection-related severity measures, i.e. total number of days with respiratory infection, and total duration of the infections. It is concluded that vitamin E supplementation does not substantially alter the immunocompetence markers DHEA and neopterin in elderly subjects, and may explain our recently reported failure of vitamin E supplementation to afford protection against acute respiratory infections.
关于维生素E的免疫刺激作用，已发表了相互矛盾的结果。采用随机安慰剂对照设计，研究了连续15个月每日补充200毫克维生素E对两种免疫能力生物标志物，即血清硫酸脱氢表雄酮（DHEA-S）和新蝶呤的影响。在该研究纳入的100名相对健康的荷兰老年人中，50人补充维生素E，50人接受安慰剂。与安慰剂相比，补充维生素E既不影响血清DHEA-S水平，也不影响血清新蝶呤水平。这与补充维生素E不影响感染相关严重程度指标（即呼吸道感染总天数和感染总持续时间）的发现相一致。得出的结论是，补充维生素E不会显著改变老年受试者的免疫能力标志物DHEA和新蝶呤，这可能解释了我们最近报道的补充维生素E未能预防急性呼吸道感染的原因。
