Wang S
Zhonghua Yi Xue Za Zhi. 1991 Feb;71(2):76-7, 8.
An epidemiological study on hepatitis C virus infection in the populations of two villages with 5-year history of plasma donation was conducted. The prevalence rates of viral hepatitis and elevated alanine aminotransferase (ALT) level in the plasmapheretic donors of these two villages were 11.3% and 33.0%, respectively. The figures were significantly higher than those in the blood donors of these two villages, (1.5% and 10.8%, respectively), and those in the adults without blood donation living in a neighbouring village (0 and 5.0%, respectively). Of 19 patients with viral hepatitis among the plasmapheretic donors tested for anti-HCV by Chiron C-100 enzyme-linked immunoassay (EIA), 17 were positive, with positive rate of 89.5%. Of 38 patients with elevated ALT levels alone, 36 were anti-HCV positive, with the positive rate of 94.7%. Anti-HAV IgM, anti-HBc IgM, anti-CMV IgM and anti-EBV IgM were not detected in any of these 55 patients. The results demonstrated that an epidemic of hepatitis C occurred among the plasmapheretic donors in these two villages with 5-year history of plasma donation.
对两个有5年血浆捐献史的村庄人群进行了丙型肝炎病毒感染的流行病学研究。这两个村庄血浆置换捐献者中病毒性肝炎患病率和丙氨酸转氨酶（ALT）水平升高率分别为11.3%和33.0%。这些数字显著高于这两个村庄的献血者（分别为1.5%和10.8%）以及居住在邻村的未献血成年人（分别为0和5.0%）。在通过Chiron C - 100酶联免疫吸附测定（EIA）检测抗HCV的血浆置换捐献者中，19例病毒性肝炎患者中有17例呈阳性，阳性率为89.5%。在仅ALT水平升高的38例患者中，36例抗HCV呈阳性，阳性率为94.7%。在这55例患者中均未检测到抗HAV IgM、抗HBc IgM、抗CMV IgM和抗EBV IgM。结果表明，在这两个有5年血浆捐献史的村庄的血浆置换捐献者中发生了丙型肝炎流行。
