Lee Su Young, Kuti Joseph L, Nicolau David P
Center for Anti-Infective Research and Development, Hartford Hospital, USA.
Conn Med. 2006 Jan;70(1):25-8.
Polymyxin B and colistin have demonstrated reasonable success in infections due to multidrug-resistant A. baumannii and P. aeruginosa. Polymyxins are only recommended for highly selected cases of serious infections caused by gram-negative bacilli resistant to currently available antibiotics to avoid their potential toxicity. Pharmacodynamic studies are still needed to determine appropriate dosage regimens that will optimize effectiveness and minimize toxicity.
多黏菌素B和黏菌素已证明在治疗由多重耐药鲍曼不动杆菌和铜绿假单胞菌引起的感染方面取得了一定成功。多黏菌素仅推荐用于由对现有抗生素耐药的革兰氏阴性杆菌引起的高度特定严重感染病例，以避免其潜在毒性。仍需要进行药效学研究来确定合适的给药方案，以优化疗效并将毒性降至最低。
