Comparison of photosensitizing effect of lipofuscin granules from retinal pigment epithelium of human donor eyes and their fluorophore A2E.

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作者信息

Dontsov A E, Sakina N L, Bilinska B, Krzyzanowski L, Feldman T B, Ostrovsky M A

机构信息

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosvgina 4, Moscow, 119991 Russia.

出版信息

Dokl Biochem Biophys. 2005 Nov-Dec;405:458-60. doi: 10.1007/s10628-005-0139-y.

DOI:10.1007/s10628-005-0139-y

PMID:16480152

Abstract

摘要

相似文献

Comparison of photosensitizing effect of lipofuscin granules from retinal pigment epithelium of human donor eyes and their fluorophore A2E.

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Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2).在 BEST1（VMD2）突变的纯合子或杂合子个体中 A2E 的蓄积增强。

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Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin.视网膜色素上皮脂褐质的主要荧光团A2E的生物合成研究。

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[A retinoid constituent of lipofuscin, A2-E, is a photosensitizer in human retinal pigment epithelial cells].脂褐质的一种类视黄醇成分A2-E是人类视网膜色素上皮细胞中的一种光敏剂。

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The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium.脂褐素成分A2E可选择性抑制视网膜色素上皮细胞对光感受器磷脂的吞噬溶酶体降解。

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The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.脂褐素荧光团A2E介导蓝光诱导的视网膜色素上皮细胞损伤。

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C20-D3-vitamin A slows lipofuscin accumulation and electrophysiological retinal degeneration in a mouse model of Stargardt disease.C20-D3-维生素 A 可减缓斯塔加特病小鼠模型中脂褐素的积累和视网膜电生理退行性变。

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Light-induced release of A2E photooxidation toxic products from lipofuscin granules of human retinal pigment epithelium.光诱导人视网膜色素上皮脂褐素颗粒释放A2E光氧化毒性产物。

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本文引用的文献

The photochemical oxidation of A2E results in the formation of a 5,8,5',8'-bis-furanoid oxide.A2E的光化学氧化作用会导致形成一种5,8,5',8'-双呋喃型氧化物。

Exp Eye Res. 2004 Oct;79(4):537-42. doi: 10.1016/j.exer.2004.06.024.

DNA is a target of the photodynamic effects elicited in A2E-laden RPE by blue-light illumination.DNA是蓝光照射富含A2E的视网膜色素上皮细胞引发的光动力效应的作用靶点。

Invest Ophthalmol Vis Sci. 2003 May;44(5):2245-51. doi: 10.1167/iovs.02-0746.

Comparison of the aerobic photoreactivity of A2E with its precursor retinal.A2E与其前体视黄醛的需氧光反应性比较。

Photochem Photobiol. 2003 Mar;77(3):253-8. doi: 10.1562/0031-8655(2003)077<0253:cotapo>2.0.co;2.

Singlet-oxygen generation from A2E.由A2E产生单线态氧。

Photochem Photobiol. 2003 Mar;77(3):235-42. doi: 10.1562/0031-8655(2003)077<0235:sogfa>2.0.co;2.

Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement.由与黄斑变性相关的脂褐素荧光团A2E形成壬氧杂环丙烷以及单线态氧参与的证据。

Angew Chem Int Ed Engl. 2002 Mar 1;41(5):814-7. doi: 10.1002/1521-3773(20020301)41:5<814::aid-anie814>3.0.co;2-2.

Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin.视网膜色素上皮脂褐质的主要荧光团A2E的生物合成研究。

J Biol Chem. 2002 Mar 1;277(9):7183-90. doi: 10.1074/jbc.M108981200. Epub 2001 Dec 26.

Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration.年龄相关性黄斑变性中的眼底自发荧光与地图样萎缩的发展

Invest Ophthalmol Vis Sci. 2001 Apr;42(5):1051-6.

The photoreactivity of the retinal age pigment lipofuscin.视网膜年龄色素脂褐质的光反应性。

J Biol Chem. 1999 Aug 20;274(34):23828-32. doi: 10.1074/jbc.274.34.23828.

Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium.从人视网膜色素上皮细胞中分离并一步制备视黄醛二聚体（A2E）和异视黄醛二聚体（iso-A2E）荧光团。

Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14609-13. doi: 10.1073/pnas.95.25.14609.

Lipofuscin is a photoinducible free radical generator.脂褐素是一种光诱导自由基发生器。

J Photochem Photobiol B. 1993 Aug;19(3):201-4. doi: 10.1016/1011-1344(93)87085-2.

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