Scholefield J H, Kerr I B, Shepherd N A, Miller K J, Bloomfield R, Northover J M
Imperial Cancer Research Fund, Colorectal Unit, St Mark's Hospital, London.
Gut. 1991 Jun;32(6):674-6. doi: 10.1136/gut.32.6.674.
An association between anal squamous cell carcinoma and human papillomavirus (HPV) type 16 DNA has been documented in the UK. If HPV type 16 is an important aetiological factor in the development of this tumour it would be expected to occur in anal cancer tissues from other parts of the world. In this study a series of 173 anal squamous cell carcinoma tissue samples from five centres around the world have been examined by DNA hybridisation for HPV type 16 DNA sequences. HPV type 16 DNA was found in 50 of 173 (29%) of these. The prevalence of HPV associated anal squamous cell carcinoma was significantly lower in tissue from India and South Africa than in the Swiss, Polish, or Brazilian samples. HPV associated anal squamous cell carcinoma does occur in other countries and further investigations of the prevalence of these tumours in association with other HPV types are required.
在英国，已证实肛门鳞状细胞癌与人乳头瘤病毒16型（HPV - 16）DNA之间存在关联。如果HPV - 16是该肿瘤发生发展的一个重要病因，那么在世界其他地区的肛门癌组织中也应该会出现。在本研究中，通过DNA杂交技术对来自世界各地五个中心的173份肛门鳞状细胞癌组织样本进行了HPV - 16 DNA序列检测。在这173份样本中，有50份（29%）检测到了HPV - 16 DNA。来自印度和南非的组织样本中，HPV相关的肛门鳞状细胞癌患病率显著低于瑞士、波兰或巴西的样本。HPV相关的肛门鳞状细胞癌在其他国家也确实存在，需要进一步调查这些肿瘤与其他HPV类型相关的患病率。
