Tidy J A, Vousden K H, Farrell P J
Ludwig Institute for Cancer Research, St Mary's Branch, St Mary's Hospital Medical School, Norfolk Place, London.
Lancet. 1989 Jun 3;1(8649):1225-7. doi: 10.1016/s0140-6736(89)92329-5.
A variant (HPV16b) of the previously described human papillomavirus (HPV)16 (now called HPV16a) has been identified by polymerase chain reaction assays. Compared with HPV16a, HPV16b has a 21bp deletion and several point mutations within the upstream regulatory region. All cervical carcinoma samples studied contained only HPV16a. HPV16b was found only rarely in cervical neoplasia but was common in the normal population.
通过聚合酶链反应检测鉴定出了先前描述的人乳头瘤病毒16型（HPV16，现称为HPV16a）的一个变体（HPV16b）。与HPV16a相比，HPV16b在上游调控区域有一个21bp的缺失和几个点突变。所有研究的宫颈癌样本仅含有HPV16a。HPV16b仅在宫颈肿瘤中罕见发现，但在正常人群中很常见。
