Rowe John, Lavender Anthony, Turk Vicky
City and Hackney Teaching Primary Care NHS Trust, and City and East London Mental Health NHS Trust, London, UK.
Br J Clin Psychol. 2006 Mar;45(Pt 1):5-17. doi: 10.1348/014466505X29594.
The study investigated executive function in adults with Down's syndrome.
Participants with Down's syndrome (N=26) were compared with non-Down syndrome learning disabled participants (N=26).
The two group's performance on a range of tests of executive function were compared. Groups were matched on age and a measure of vocabulary.
The Down's syndrome group performed at a significantly lower level on a number of tests of executive function.
It is suggested that impaired executive function in Down's syndrome is due to abnormal development of the prefrontal cortex in Down's syndrome. Tests of executive function may be sensitive to cognitive changes with the onset of dementia in people with Down's syndrome. Longitudinal studies examining changes in executive function in people with Down's syndrome are recommended.
本研究调查了唐氏综合征成年人的执行功能。
将唐氏综合征参与者（N = 26）与非唐氏综合征学习障碍参与者（N = 26）进行比较。
比较两组在一系列执行功能测试中的表现。两组在年龄和词汇量测量方面进行了匹配。
唐氏综合征组在多项执行功能测试中的表现明显较低。
提示唐氏综合征患者执行功能受损是由于唐氏综合征患者前额叶皮质发育异常所致。执行功能测试可能对唐氏综合征患者痴呆症发作时的认知变化敏感。建议进行纵向研究以检查唐氏综合征患者执行功能的变化。
