Machado-Vieira Rodrigo, Dietrich Marcelo O, Leke Renata, Cereser Vitor H, Zanatto Vanessa, Kapczinski Flavio, Souza Diogo O, Portela Luis V, Gentil Valentim
Mood Disorders Program, Fundação Faculdade Federal Ciências Medicas de Porto Alegre, Bipolar Disorder Research Program, Espírita Hospital of Porto Alegre, Porto Alegre, Brazil.
Biol Psychiatry. 2007 Jan 15;61(2):142-4. doi: 10.1016/j.biopsych.2006.03.070. Epub 2006 Aug 7.
Bipolar disorder (BD) has been increasingly associated with abnormalities in neuroplasticity and cellular resilience. Brain Derived Neurotrophic Factor (BDNF) gene has been considered an important candidate marker for the development of bipolar disorder and this neurotrophin seems involved in intracellular pathways modulated by mood stabilizers. Also, previous studies demonstrated a role for BDNF in the pathophysiology and clinical presentation of mood disorders.
We investigated whether BDNF levels are altered during mania. Sixty subjects (14 M and 46 F) were selected and included in the study. Thirty patients meeting SCID-I criteria for manic episode were age and gender matched with thirty healthy controls. Young Mania Rating Scale (YMRS) evaluated the severity of manic episode and its possible association with the neurotrophin levels.
Mean BDNF levels were significantly decreased in drug free/naive (224.8 +/- 76.5 pg/ml) compared to healthy controls (318.5 +/- 114.2), p < .001]. Severity of the manic episode presented a significant negatively correlation to plasma BDNF levels (r= .78; p < .001; Pearson test).
Overall, these results suggest that the decreased plasma BDNF levels may be directly associated with the pathophysiology and severity of manic symptoms in BD. Further studies are necessary to clarify the role of BDNF as a putative biological marker in BD.
双相情感障碍（BD）越来越多地与神经可塑性和细胞弹性异常相关。脑源性神经营养因子（BDNF）基因被认为是双相情感障碍发展的重要候选标志物，并且这种神经营养因子似乎参与了由心境稳定剂调节的细胞内信号通路。此外，先前的研究表明BDNF在心境障碍的病理生理学和临床表现中起作用。
我们研究了躁狂发作期间BDNF水平是否发生改变。选择60名受试者（14名男性和46名女性）纳入研究。30名符合SCID-I标准的躁狂发作患者在年龄和性别上与30名健康对照匹配。青年躁狂评定量表（YMRS）评估躁狂发作的严重程度及其与神经营养因子水平的可能关联。
与健康对照（318.5±114.2）相比，未用药/初治患者的平均BDNF水平显著降低（224.8±76.5 pg/ml），p <.001]。躁狂发作的严重程度与血浆BDNF水平呈显著负相关（r =.78；p <.001；Pearson检验）。
总体而言，这些结果表明血浆BDNF水平降低可能与双相情感障碍中躁狂症状的病理生理学和严重程度直接相关。需要进一步研究以阐明BDNF作为双相情感障碍假定生物标志物的作用。
