De Felice Gianmarco, Luciano Mario, Boiano Alessia, Colangelo Giulia, Catapano Pierluigi, Della Rocca Bianca, Lapadula Maria Vita, Piegari Elena, Toni Claudia, Fiorillo Andrea
Department of Psychiatry, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Brain Sci. 2023 Aug 20;13(8):1221. doi: 10.3390/brainsci13081221.
Brain-derived neurotrophic factor (BDNF) plays a key role in brain development, contributing to neuronal survival and neuroplasticity. Previous works have found that BDNF is involved in several neurological or psychiatric diseases. In this review, we aimed to collect all available data on BDNF and bipolar disorder (BD) and assess if BDNF could be considered a biomarker for BD. We searched the most relevant medical databases and included studies reporting original data on BDNF circulating levels or Val66Met polymorphism. Only articles including a direct comparison with healthy controls (HC) and patients diagnosed with BD according to international classification systems were included. Of the 2430 identified articles, 29 were included in the present review. Results of the present review show a reduction in BDNF circulating levels during acute phases of BD compared to HC, which increase after effective therapy of the disorders. The Val66Met polymorphism was related to features usually associated with worse outcomes. High heterogeneity has been observed regarding sample size, clinical differences of included patients, and data analysis approaches, reducing comparisons among studies. Although more studies are needed, BDNF seems to be a promising biomarker for BD.
脑源性神经营养因子（BDNF）在大脑发育中起关键作用，有助于神经元存活和神经可塑性。先前的研究发现BDNF与多种神经或精神疾病有关。在本综述中，我们旨在收集所有关于BDNF和双相情感障碍（BD）的可用数据，并评估BDNF是否可被视为BD的生物标志物。我们检索了最相关的医学数据库，并纳入了报告BDNF循环水平或Val66Met多态性原始数据的研究。仅纳入了与健康对照（HC）以及根据国际分类系统诊断为BD的患者进行直接比较的文章。在2430篇已识别的文章中, 本综述纳入了29篇。本综述结果显示，与HC相比，BD急性期BDNF循环水平降低，疾病有效治疗后升高。Val66Met多态性与通常与较差预后相关的特征有关。在样本量、纳入患者的临床差异和数据分析方法方面观察到高度异质性，减少了研究间的比较。尽管还需要更多研究，但BDNF似乎是BD一个有前景的生物标志物。
