Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung County 833, Taiwan.
Neurosci Lett. 2009 Dec 11;466(3):139-43. doi: 10.1016/j.neulet.2009.09.044. Epub 2009 Sep 26.
Evidence has suggested a role of brain-derived neurotrophic factor (BDNF) in the pathogenesis of bipolar disorder (BD). Recent studies have examined BDNF levels in BD patients, but showed inconsistent results. In current study, meta-analyses by random-effects model were performed to compare blood BDNF levels between BD patients and healthy controls, and examine patients based on different affective status (manic, depressed, or euthymic state). Fifteen studies from 10 citations were included into the analysis. Pooling of results from all studies indicated that, overall, patients with BD had a lower level of BDNF than healthy controls (p=1x10(-4)). But when separating these studies based on different affective status, it showed that the significance existed only when comparing patients in manic (p=0.0008) or depressed (p=0.02) state with controls, but not in euthymic state (p=0.25). In addition, BDNF level was significantly increased after pharmacological treatment of manic state (p=0.01). These findings indicate that BDNF levels are abnormally reduced in manic and depressed states of BD, and the reduced level in manic state increases after treatment. They suggest a role of blood BDNF level as a state-dependent biomarker of bipolar disorder.
有证据表明脑源性神经营养因子（BDNF）在双相情感障碍（BD）的发病机制中起作用。最近的研究已经检查了 BD 患者的 BDNF 水平，但结果不一致。在目前的研究中，采用随机效应模型进行荟萃分析，以比较 BD 患者和健康对照组之间的血液 BDNF 水平，并根据不同的情感状态（躁狂、抑郁或轻躁狂状态）检查患者。从 10 篇参考文献中纳入了 15 项研究进行分析。所有研究的汇总结果表明，总体而言，BD 患者的 BDNF 水平低于健康对照组（p=1x10(-4))。但是，当根据不同的情感状态对这些研究进行分类时，结果显示，只有在比较躁狂（p=0.0008）或抑郁（p=0.02）患者与对照组时才具有显著性，而在轻躁狂状态时则不具有显著性（p=0.25）。此外，在躁狂状态的药物治疗后，BDNF 水平显著升高（p=0.01）。这些发现表明，BDNF 水平在 BD 的躁狂和抑郁状态下异常降低，而躁狂状态下的降低水平在治疗后增加。它们表明血液 BDNF 水平作为双相情感障碍的状态依赖性生物标志物的作用。
