Kazal L A, Erslev A J
Ann Clin Lab Sci. 1975 Mar-Apr;5(2):98-109.
A review of the pertinent literature on the relation of erythropoietin production to the presence of renal neoplasm suggests that erythropoietin may be produced either directly by the tumor or indirectly by its physical effect on the adjoining normal renal tissue. The most commonly found tumors which are associated with elevated levels of serum and urinary erythropoietin are the hypernephromas. However, the presence of erythropoietin and an associated erythrocytosis even here occurs only relatively infrequently. Some studies have demonstrated the presence of erythropoietin activity in tumor tissue itself but erythropoietin has not been isolated from renal tumor tissue. In some patients with Wilms' tumor, erythropoietin blood levels may also be increased; however, erythrocytosis in these patients is not a characteristic feature. Other renal tumors rarely produce erythrocytosis and presumably no erythropoietin. Possible explanations for the production of erythropoietin by renal tumors are discussed.
一篇关于促红细胞生成素产生与肾肿瘤存在关系的相关文献综述表明，促红细胞生成素可能由肿瘤直接产生，也可能通过其对毗邻正常肾组织的物理作用间接产生。与血清和尿促红细胞生成素水平升高相关的最常见肿瘤是肾细胞癌。然而，即使在这里，促红细胞生成素和相关红细胞增多症的出现也相对较少。一些研究已证实在肿瘤组织本身存在促红细胞生成素活性，但尚未从肾肿瘤组织中分离出促红细胞生成素。在一些患有肾母细胞瘤的患者中，促红细胞生成素的血液水平也可能升高；然而，这些患者的红细胞增多症并非特征性表现。其他肾肿瘤很少产生红细胞增多症，推测也不产生促红细胞生成素。文中讨论了肾肿瘤产生促红细胞生成素的可能原因。
