Yoshida T, Kin S, Kounami T
Department of Urology, Otsu Municipal Hospital.
Hinyokika Kiyo. 1997 May;43(5):339-42.
A case of erythropoietin-producing renal cell carcinoma is reported. A 59-year-old woman was referred to our hospital for further examination of erythrocytosis accompanied with an elevated serum erythropoietin level. Ultrasonography and computerized tomography scan showed a left renal tumor. She underwent a left radical nephrectomy. Postoperatively, serum erythropoietin level and erythrocytosis were normalized. Histopathology was renal cell carcinoma, clear cell subtype, and immunohistochemistry revealed erythropoietin in cancer cells. Furthermore, the cancerous tissue contained a high concentration of erythropoietin.
报告一例产生促红细胞生成素的肾细胞癌病例。一名59岁女性因伴有血清促红细胞生成素水平升高的红细胞增多症前来我院进一步检查。超声检查和计算机断层扫描显示左肾肿瘤。她接受了左肾根治性切除术。术后,血清促红细胞生成素水平和红细胞增多症恢复正常。组织病理学检查为肾细胞癌,透明细胞亚型,免疫组织化学显示癌细胞中有促红细胞生成素。此外,癌组织中促红细胞生成素浓度很高。