Burk J R, Lertora J J, Martinez I R, Fisher J W
South Med J. 1977 Aug;70(8):955-58. doi: 10.1097/00007611-197708000-00017.
A case study is presented of a 55-year-old man who had clear cell renal carcinoma with pulmonary metastases and erythrocytosis. The increase in red blood cell mass was associated with an elevation in erythropoietic stimulatory activity in serum, pleural fluid, and tumor-cyst fluid as determined by the exhypoxic polycythemic mouse assay. It is postulated that the increased erythropoietic stimulatory activity represents autonomous tumor secretion of erythropoietin or an erythropoietin-like material. Electron microscopic studies confirmed the proximal tubular origin of this tumor.
本文报道了一例55岁男性患者，患有透明细胞肾细胞癌并伴有肺转移和红细胞增多症。通过低氧性红细胞增多症小鼠试验测定，红细胞增多与血清、胸腔积液和肿瘤囊液中促红细胞生成刺激活性升高有关。据推测，促红细胞生成刺激活性增加代表肿瘤自主分泌促红细胞生成素或类促红细胞生成素物质。电子显微镜研究证实了该肿瘤起源于近端肾小管。
