寻找卡波西肉瘤相关疱疹病毒的靶细胞。
Looking for the target cell of Kaposi's sarcoma-associated herpesvirus.
作者信息
Dupin Nicolas, Grange Philippe A
机构信息
Service de Dermatologie, Hôpital Cochin, Laboratoire de Recherche en Dermatologie, Unité UPRES1833, Faculté de Médecine Paris V, Université René Descartes, Paris, France.
出版信息
J Invest Dermatol. 2006 Mar;126(3):545-7. doi: 10.1038/sj.jid.5700132.
The level of Kaposi's sarcoma-associated herpesvirus (KSHV) cellular viremia in patients with Kaposi's sarcoma could be related to both the tumor burden and its progression. The origin of the spindle cell, the hallmark cell of Kaposi's sarcoma, is still debated. Two hypotheses may be formulated, favoring a lymphatic endothelial cell or an endothelial-cell precursor evolving into a lymphatic phenotype, both preferentially targeted by KSHV.
卡波西肉瘤患者体内卡波西肉瘤相关疱疹病毒（KSHV）的细胞病毒血症水平可能与肿瘤负荷及其进展均有关。卡波西肉瘤的标志性细胞——梭形细胞的起源仍存在争议。可能有两种假说，一种认为是淋巴内皮细胞，另一种认为是演变成淋巴表型的内皮细胞前体，这两种细胞均是KSHV的优先靶向目标。
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