两名HIV阴性患者的孤立性卡波西肉瘤
Isolated Kaposi Sarcoma in two HIV negative patients.
作者信息
Seleit Iman, Attia Abdalla, Maraee Alaa, Samaka Rehab, Bakry Ola, Eid Emad
机构信息
Department of Dermatology, Andrology and S.T.Ds, Faculty of Medicine, Menoufiya University, Egypt.
出版信息
J Dermatol Case Rep. 2011 Jun 6;5(2):24-6. doi: 10.3315/jdcr.2011.1067.
BACKGROUND
Kaposi sarcoma (KS) is a neoplasm of the endothelial cells. It often manifests with multiple vascular nodules on the skin and other organs. It is a systemic, malignant and multifactorial disease and has a variable course. There are four types: classic, endemic, iatrogenic and HIV-associated. The primary presentation on the penis and face is uncommon and is mainly observed in HIV-positive patients. Multiple treatment modalities are used including surgery, cryotherapy, electrosurgery, laser and radiation therapy.
MAIN OBSERVATION
The authors present two cases of isolated Kaposi sarcoma in HIV negative, human herpes virus 8 (HHV-8) positive non immunocompromised patients. One case with facial KS and the other one with penile KS. Both were treated surgically with no recurrence in the following 6 months of the follow up period.
CONCLUSIONS
Kaposi sarcoma is rare in HIV negative patients and is associated with HHV-8 infection. Lesions are usually solitary and can be treated surgically. It should be included in the differential diagnoses of penile and facial lesions that are clinically suspecious and resistent to therapy.
背景
卡波西肉瘤（KS）是一种内皮细胞肿瘤。它常表现为皮肤和其他器官上的多个血管结节。它是一种全身性、恶性且多因素的疾病，病程多变。有四种类型：经典型、地方性、医源性和与HIV相关型。阴茎和面部的原发性表现并不常见，主要见于HIV阳性患者。多种治疗方式被采用，包括手术、冷冻疗法、电外科手术、激光和放射治疗。
主要观察结果
作者报告了两例HIV阴性、人疱疹病毒8（HHV-8）阳性的非免疫功能低下患者的孤立性卡波西肉瘤病例。一例为面部KS，另一例为阴茎KS。两例均接受了手术治疗，在接下来的6个月随访期内均无复发。
结论
卡波西肉瘤在HIV阴性患者中罕见，与HHV-8感染有关。病变通常为孤立性，可通过手术治疗。对于临床上可疑且治疗无效的阴茎和面部病变，应将其纳入鉴别诊断。
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