Froehlich J C, Zweifel M, Harts J, Lumeng L, Li T K
Department of Medicine, Indiana University School of Medicine, Indianapolis.
Psychopharmacology (Berl). 1991;103(4):467-72. doi: 10.1007/BF02244246.
We have previously reported that naloxone, a nonspecific opioid receptor antagonist, suppresses alcohol but not water consumption by male rats that have been genetically selected for high voluntary alcohol drinking. However, the identity of the specific opioid receptor subtype that may mediate alcohol drinking is not known. This paper reports that a selective delta opioid receptor antagonist is as effective as naloxone in suppressing alcohol consumption and that an enkephalinase inhibitor, which potentiates the action of endogenous enkephalins, increases alcohol intake. These results suggest that alcohol-induced activation of the endogenous enkephalinergic system, and occupation of delta opioid receptors, are involved in the maintenance of continued alcohol drinking.
我们之前曾报道，纳洛酮，一种非特异性阿片受体拮抗剂，可抑制经基因筛选具有高自愿饮酒量的雄性大鼠的酒精摄入量，但不影响其饮水量。然而，介导酒精饮用的特定阿片受体亚型的身份尚不清楚。本文报道，一种选择性δ阿片受体拮抗剂在抑制酒精摄入量方面与纳洛酮同样有效，而一种增强内源性脑啡肽作用的脑啡肽酶抑制剂会增加酒精摄入量。这些结果表明，酒精诱导的内源性脑啡肽能系统的激活以及δ阿片受体的占据，参与了持续饮酒行为的维持。
