Rossi Ernest Lawrence
Am J Clin Hypn. 2005;48(2-3):165-82. doi: 10.1080/00029157.2005.10401514.
A new perspective on how therapeutic hypnosis and neuroscience may be integrated on the molecular-genomic level is offered as a guide for basic research and clinical applications. An update of Watson and Crick's original formulation of molecular biology is proposed to illustrate how psychosocial experiences modulate gene expression, protein synthesis, and brain plasticity during memory trace reactivation for the reorganization of neural networks that encode fear, stress, and traumatic symptoms. Examples of the scientific literature on DNA microarrays are used to explore how this new technology could integrate therapeutic hypnosis, neuroscience, and psychosocial genomics as a new foundation for mind-body medicine. Researchers and clinicians in therapeutic hypnosis need to partner with colleagues in neuroscience and molecular biology that utilize DNA microarray technology. It is recommended that hypnotic susceptibility scales of the future incorporate gene expression data to include the concept of "embodied imagination" and the "ideo-plastic faculty" on a molecular-genomic level as well as the psychological and behavioral level of ideomotor and ideosensory responses that are currently assessed.
本文提供了一个关于治疗性催眠与神经科学如何在分子基因组水平上整合的新视角，作为基础研究和临床应用的指南。本文提出了对沃森和克里克最初分子生物学理论的更新，以说明心理社会经历如何在记忆痕迹重新激活过程中调节基因表达、蛋白质合成和大脑可塑性，从而实现对编码恐惧、压力和创伤症状的神经网络进行重组。文中引用了DNA微阵列科学文献的例子，探讨这项新技术如何将治疗性催眠、神经科学和心理社会基因组学整合起来，作为身心医学的新基础。治疗性催眠领域的研究人员和临床医生需要与运用DNA微阵列技术的神经科学和分子生物学领域的同事合作。建议未来的催眠易感性量表纳入基因表达数据，以便在分子基因组水平以及当前所评估的观念运动和观念感觉反应的心理和行为水平上，纳入“具身想象”和“观念塑造能力”的概念。
