Atkinson David, Iannotti Salvatore, Cozzolino Mauro, Castiglione Stefano, Cicatelli Angela, Vyas Bhaskar, Mortimer Jane, Hill Richard, Chovanec Erika, Chiamberlando Alessia, Cuadros Jorge, Virot Claude, Kerouac Michel, Kallfass Thierry, Krippner Stanley, Frederick Claire, Gregory Bruce, Shaffran Michael, Bullock Margaret, Soleimany Ella, Rossi April Cybelle, Rossi Kathryn, Rossi Ernest
University of Pittsburgh School of Medicine, USA.
Am J Clin Hypn. 2010 Jul;53(1):27-46. doi: 10.1080/00029157.2010.10401745.
In a 2008 pilot study we used DNA microarrays to explore the historical ideo-plastic faculty of therapeutic hypnosis. We documented how to measure changes in activity or experience-dependent gene expression over relatively brief time periods (1 hour and 24 hours) following a single intervention of therapeutic hypnosis (about 1 hour). In the present paper we utilize bioinformatic software to explore the possible meaning and significance of this ideo-plastic faculty of therapeutic hypnosis. Indications suggest that the ideo-plastic process of therapeutic hypnosis may be associated with (1) the heightening of a molecular-genomic signature for the up-regulation (heightened activity) of genes characteristic of stem cell growth, (2) a reduction in cellular oxidative stress, and (3) a reduction in chronic inflammation. We identify these three empirical associations as an initial beta version of the molecular-genomic signature of the ideo-plastic process of therapeutic hypnosis, which can serve as a theoretical and practical guide for clinical excellence by beginners as well as senior professionals. We propose this molecular-genomic level of discourse as a supplement to the traditional cognitive-behavioral description of therapeutic suggestion, hypnosis, and psychotherapy that is consistent with "translational research" currently funded by the National Institute of Mental Health (NIMH).
在2008年的一项初步研究中，我们使用DNA微阵列来探究治疗性催眠的历史观念塑造能力。我们记录了在单次治疗性催眠干预（约1小时）后的相对较短时间段（1小时和24小时）内，如何测量与活动或经验相关的基因表达变化。在本文中，我们利用生物信息学软件来探究治疗性催眠这种观念塑造能力的可能意义和重要性。迹象表明，治疗性催眠的观念塑造过程可能与以下方面有关：（1）干细胞生长特征基因上调（活性增强）的分子基因组特征增强；（2）细胞氧化应激的降低；（3）慢性炎症的减轻。我们将这三种实证关联确定为治疗性催眠观念塑造过程的分子基因组特征的初始测试版，可为初学者以及资深专业人员提供卓越临床实践的理论和实践指导。我们提出这种分子基因组层面的论述，作为对治疗性暗示、催眠和心理治疗的传统认知行为描述的补充，这与美国国立精神卫生研究所（NIMH）目前资助的“转化研究”相一致。
