Agaba Emmanuel I, Duguru Mary, Agaba Patricia A, Angbazo Dorcas
Department of Medicine, Jos University Teaching Hospital, Jos, P. O. Box 2076, Nigeria.
West Afr J Med. 2005 Oct-Dec;24(4):305-8. doi: 10.4314/wajm.v24i4.28221.
End stage renal disease (ESRD) and diabetes mellitus may have lipid abnormalities that act synergistically to place diabetics with ESRD at an augmented risk for cardiovascular morbidity and mortality. We studied serum lipid profile and risk ratio in Nigerian diabetics with ESRD as there is no data in this regard.
Serum lipid profile was determined in the fasting state for consecutive diabetic patients with ESRD seen in the Nephrology Unit of the Jos University Teaching Hospital over a 2- year period. A similar group of non- diabetic patients with ESRD and healthy individuals served as controls.
A total of 21 diabetics and 30 non- diabetics both with ESRD and 36 controls were studied. High-density lipoprotein (HDL) cholesterol levels were lower in diabetics compared to controls (1.55 +/- 1.14 mmol/L vs. 2.38 +/- 0.57 mmol/L, p < 0.05) but similar to that of the non- diabetic group. On the contrary, low-density lipoprotein (LDL) cholesterol levels were higher in diabetics compared to controls (2.87 +/- 2.07 mmol/L vs. 1.44 + 0.52 mmol/L, p < 0.05). Serum Triglyceride and total Cholesterol levels were similar in all study groups. The LDL/HDL cholesterol ratio was higher in diabetics compared to non- diabetics and controls (3.65 +/- 3.97, 2.08 +/- 1.72, 0.61 +/- 0.30 respectively, p < 0.0001; multiple comparison p < 0.05).
Cardiovascular risk as imposed by lipid abnormalities is elevated in Nigerian diabetic persons with ESRD compared to their non- diabetic counterparts as reported elsewhere.
终末期肾病（ESRD）和糖尿病可能存在脂质异常，二者相互作用，使患有ESRD的糖尿病患者发生心血管疾病的发病率和死亡率风险增加。由于缺乏这方面的数据，我们对尼日利亚患有ESRD的糖尿病患者的血脂谱和风险比进行了研究。
在乔斯大学教学医院肾病科对连续2年就诊的患有ESRD的糖尿病患者在空腹状态下测定血脂谱。选取一组患有ESRD的非糖尿病患者和健康个体作为对照。
共研究了21例患有ESRD的糖尿病患者、30例患有ESRD的非糖尿病患者以及36名对照者。与对照组相比，糖尿病患者的高密度脂蛋白（HDL）胆固醇水平较低（1.55±1.14 mmol/L对2.38±0.57 mmol/L，p<0.05），但与非糖尿病组相似。相反，与对照组相比，糖尿病患者的低密度脂蛋白（LDL）胆固醇水平较高（2.87±2.07 mmol/L对1.44 + 0.52 mmol/L，p<0.05）。所有研究组的血清甘油三酯和总胆固醇水平相似。糖尿病患者的LDL/HDL胆固醇比值高于非糖尿病患者和对照组（分别为3.65±3.97、2.08±1.72、0.61±0.30，p<0.0001；多重比较p<0.05）。
与其他地方报道的情况一样，与非糖尿病患者相比，尼日利亚患有ESRD的糖尿病患者因脂质异常导致的心血管疾病风险升高。
