尼日利亚西南部透析前患者血脂异常的评估。

Assessment of dyslipidemia in pre-dialysis patients in south-west Nigeria.

作者信息

Akpan Effiong Ekong, Ekrikpo Udeme Ekpenyong, Effa Emmanuel Edet, Udo Aniema Isaac Assam, Kadiri Solomon

机构信息

Department of Internal Medicine, University of Uyo Teaching Hospital, Uyo, Nigeria.

Department of Internal Medicine, University of Calabar Teaching Hospital, Calabar, Nigeria.

出版信息

Niger Med J. 2014 May;55(3):214-9. doi: 10.4103/0300-1652.132043.

DOI:10.4103/0300-1652.132043

PMID:25013252

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4089049/

Abstract

BACKGROUND

Majority of chronic kidney disease (CKD) patients are more likely to die of cardiovascular complications before reaching end stage renal disease. The Kidney Disease Outcomes Quality Initiative (K/DOQI) recommends that all CKD patients should be evaluated for dyslipidemia and for treatment to reduce the risk of cardiovascular events.

PATIENTS AND METHODS

A cross-sectional case control study to determine the frequency of occurrence of lipid abnormalities in patients with CKD and compare these abnormalities with that of normal controls. A total of 100 patients and 100 controls were recruited for the study. Demographic and clinical data were obtained using structured questionnaire. Weight, height and waist circumference, body mass index (BMI) and blood pressure were also obtained. Subjects had their fasting lipid profile and fasting plasma glucose assayed after overnight fast of 8-14 hours. Low-density lipoprotein (LDL) was obtained using Friedwald formula.

RESULT

The study revealed that total cholesterol (TC) was elevated above normal levels in 44% of cases compared with 6% in controls (P < 0.001), with the mean (SD) value of 5.82 ± 3.28 mmol/l for cases compared with 3.9 ± 1.0 mmol/l (P < 0.001) in controls. Low density lipoprotein was elevated in 48% of cases compared with 14% in controls (P < 0.001), with the mean (SD) values of 4.15 ± 2.74 mmol/l and 2.57 ± 0.95 mmol/l for cases and controls, respectively, (P < 0.001). Triglyceride (TG) was elevated above normal level in 26% of cases compared with none in the controls (P < 0.001), with the mean (SD) values of 1.41 ± 1.10 mmol/l and 0.64 ± 0.24 mmol/l for cases and controls, respectively (P < 0.001). All Lipid fractions except HDL also correlated significantly with levels of proteinuria TC (r = 0.345, P = 0.001), TG (r = 0.268, P = 0.011) LDL (r = 0.366, P = 0.001).

CONCLUSION

Dyslipidemia is common among patients with CKD. Regular evaluation of all CKD patients for dyslipidemia and treatment need be instituted.

摘要

背景

大多数慢性肾脏病（CKD）患者在进入终末期肾病之前更有可能死于心血管并发症。肾脏病预后质量倡议组织（K/DOQI）建议，所有CKD患者都应接受血脂异常评估，并进行治疗以降低心血管事件风险。

患者与方法

一项横断面病例对照研究，以确定CKD患者血脂异常的发生率，并将这些异常情况与正常对照组进行比较。共招募了100例患者和100名对照参与研究。使用结构化问卷获取人口统计学和临床数据。还测量了体重、身高、腰围、体重指数（BMI）和血压。受试者在禁食8 - 14小时后进行空腹血脂谱和空腹血糖检测。低密度脂蛋白（LDL）采用Friedwald公式计算。

结果

研究显示，44%的病例总胆固醇（TC）高于正常水平，而对照组为6%（P < 0.001），病例组的平均（标准差）值为5.82 ± 3.28 mmol/l，对照组为3.9 ± 1.0 mmol/l（P < 0.001）。48%的病例低密度脂蛋白升高，而对照组为14%（P < 0.001），病例组和对照组的平均（标准差）值分别为4.15 ± 2.74 mmol/l和2.57 ± 0.95 mmol/l（P < 0.001）。26%的病例甘油三酯（TG）高于正常水平，而对照组无升高（P < 0.001），病例组和对照组的平均（标准差）值分别为1.41 ± 1.10 mmol/l和0.64 ± 0.24 mmol/l（P < 0.001）。除高密度脂蛋白外，所有血脂成分也与蛋白尿水平显著相关：TC（r = 0.345，P = 0.001）、TG（r = 0.268，P = 0.011）、LDL（r = 0.366，P = 0.001）。