Mitra Biswadev, Fitzgerald Mark, Cameron Peter, Cleland Heather
The Alfred Emergency and Trauma Centre, Prahran, Victoria 3181, Australia.
ANZ J Surg. 2006 Jan-Feb;76(1-2):35-8. doi: 10.1111/j.1445-2197.2006.03641.x.
The Parkland formula is established as the "gold standard" for initial fluid resuscitation for major burns. The purpose of this study was to review our fluid resuscitation practice for major burns to determine whether anecdotal observations of significant variations from the Parkland formula were wide spread and whether any difference could be used as a basis for a revision of fluid resuscitation in major burns.
A retrospective review of 127 presentations to The Alfred Burns Unit with total body surface area (TBSA) affected > or =15% was conducted. A retrospective review of the resuscitation data from these patients was compared with the Parkland formula as well as other studies.
A total of 49 patients with complete data on fluid administration and uncomplicated burns were included in the analysis. Significantly larger volumes of fluid (5.58 mL/kg per %TBSA) were given to these patients in the first 24 h than predicted by the Parkland formula. Mean arterial pressure, pulse rate and urine output were at satisfactory levels. Clinically evident complications from fluid administration were minimal. Mortality was similar to that in other centres.
Fluid resuscitation volumes significantly higher than those predicted by the Parkland formula were given, without adverse consequences. This retrospective review supports a prospective, multicentre, randomized, controlled study comparing this study with the Parkland formula, resulting in a better guide to initial fluid resuscitation in major burns.
帕克兰公式已成为大面积烧伤初始液体复苏的“金标准”。本研究的目的是回顾我们对大面积烧伤的液体复苏实践,以确定与帕克兰公式存在显著差异的传闻性观察结果是否广泛存在,以及是否可以将任何差异作为修订大面积烧伤液体复苏方案的依据。
对阿尔弗雷德烧伤科收治的127例烧伤患者进行回顾性研究,这些患者的烧伤总面积(TBSA)≥15%。将这些患者的复苏数据回顾性分析结果与帕克兰公式以及其他研究进行比较。
共有49例有完整液体输注数据且烧伤无并发症的患者纳入分析。这些患者在伤后24小时内接受的液体量(5.58 mL/kg per %TBSA)显著多于帕克兰公式的预测值。平均动脉压、脉搏率和尿量均处于满意水平。液体输注导致的明显临床并发症极少。死亡率与其他中心相似。
给予的液体复苏量显著高于帕克兰公式的预测值,但未产生不良后果。这项回顾性研究支持开展一项前瞻性、多中心、随机对照研究,将本研究结果与帕克兰公式进行比较,从而为大面积烧伤的初始液体复苏提供更好的指导。