Ingason Andrés, Søeby Karen, Timm Sally, Wang August G, Jakobsen Klaus D, Fink-Jensen Anders, Hemmingsen Ralf, Berg Rasmussen Henrik, Werge Thomas
Research Institute of Biological Psychiatry, Copenhagen University Hospital, H:S Sct. Hans Hospital, DK-4000 Roskilde, Denmark.
Schizophr Res. 2006 Mar;83(1):1-5. doi: 10.1016/j.schres.2005.12.850. Epub 2006 Feb 17.
Neuregulin 1 has been implicated as a susceptibility gene in schizophrenia. Several research groups have reported association with the 5' end of the gene although no causative variant has been reported. We have investigated whether there is association with the 5' end of the gene in Danish schizophrenia patients. We found that the at-risk haplotype initially reported in the Icelandic population was not found in significant excess (or = 1.4, p = 0.12). The haplotype structure in the Danish sample was similar to that of other reported in other Caucasian populations and highly different from that of Chinese.
神经调节蛋白1已被认为是精神分裂症的一个易感基因。几个研究小组报告了该基因5'端的关联性，尽管尚未报告致病变体。我们研究了丹麦精神分裂症患者中该基因5'端是否存在关联性。我们发现，最初在冰岛人群中报告的风险单倍型并未显著过量存在（比值比 = 1.4，p = 0.12）。丹麦样本中的单倍型结构与其他报道的高加索人群相似，与中国人的单倍型结构差异很大。
