Penn Helen E
Clinical-Developmental Psychology Program, York University, Toronto, Ontario M3J IP3, Canada.
Child Neuropsychol. 2006 Feb;12(1):57-79. doi: 10.1080/09297040500253546.
This review paper integrates recent structural and functional imaging, postmortem, animal lesion, and neurochemical research about the pathophysiology of autism. An understanding of the neurobiological correlates of autism is becoming increasingly important as more children are diagnosed with the condition and funding for well-targeted interventions increases. Converging evidence suggests that autism involves abnormalities in brain volume, neurotransmitter systems, and neuronal growth. In addition, evidence firmly links autism with abnormalities in the cerebellum, the medial temporal lobe, and the frontal lobe. Potential implications of these findings and suggestions for future research are reviewed.
这篇综述文章整合了近期关于自闭症病理生理学的结构和功能成像、尸检、动物损伤及神经化学研究。随着越来越多的儿童被诊断出患有自闭症且针对性干预的资金投入增加，了解自闭症的神经生物学关联变得愈发重要。越来越多的证据表明，自闭症涉及脑容量、神经递质系统及神经元生长方面的异常。此外，证据确凿地将自闭症与小脑、颞中叶及额叶的异常联系起来。本文对这些研究结果的潜在影响及未来研究建议进行了综述。
