Hrdlicka Michal
Department of Child Psychiatry, Charles University, 2nd Faculty of Medicine, V Uvalu 84, 15006 Prague, Czech Republic.
Neuro Endocrinol Lett. 2008 Jun;29(3):281-6.
Structural neuroimaging studies done by means of magnetic resonance imaging (MRI) have provided important insights into the neurobiological basis for autism. The aim of this article is to review the current state of knowledge regarding structural brain abnormalities in autism. Results of MRI studies dealing with total brain volume, the volume of the cerebellum, caudate nucleus, thalamus, amygdala, hippocampus and the area of the corpus callosum are summarized. Existing research suggests that autistic individuals have larger total brain, cerebellar and caudate nucleus volumes; however, the area of the corpus callosum is reduced. Results of studies involving the amygdala and hippocampus volume in autistic subjects remain inconsistent and no changes have been detected in thalamic volume.
通过磁共振成像（MRI）进行的结构神经影像学研究为自闭症的神经生物学基础提供了重要见解。本文旨在综述目前关于自闭症患者大脑结构异常的知识现状。总结了有关全脑体积、小脑、尾状核、丘脑、杏仁核、海马体体积以及胼胝体面积的MRI研究结果。现有研究表明，自闭症患者的全脑、小脑和尾状核体积较大；然而，胼胝体面积减小。关于自闭症患者杏仁核和海马体体积的研究结果仍不一致，丘脑体积未发现变化。
