Brown R S, Beaver W T, Bottomley W K
Department of Oral Diagnostic Sciences, University of Texas, Houston.
J Oral Pathol Med. 1991 May;20(5):201-9. doi: 10.1111/j.1600-0714.1991.tb00419.x.
Proposed mechanisms of the side effect of drug-induced gingival hyperplasia are reviewed. Hypotheses with regard to inflammation from bacterial plaque, increased sulfated glycosaminoglycans, immunoglobulins, gingival fibroblast phenotype population differences, epithelial growth factor, pharmacokinetics and tissuebinding, collagenase activation, disruption of fibroblast cellular sodium/calcium flux, folic acid and a combination hypothesis are evaluated.
本文综述了药物性牙龈增生副作用的潜在机制。对有关细菌菌斑炎症、硫酸化糖胺聚糖增加、免疫球蛋白、牙龈成纤维细胞表型群体差异、上皮生长因子、药代动力学和组织结合、胶原酶激活、成纤维细胞钠/钙通量破坏、叶酸以及综合假说等假设进行了评估。
