Damdoum Marah, Varma Sudhir R, Nambiar Manjusha, Venugopal Adith
Department of Periodontics, University of Buffalo, New York, USA.
Department of Clinical Sciences, College of Dentistry, Ajman University, Ajman, UAE.
J Int Soc Prev Community Dent. 2022 Jun 29;12(3):309-322. doi: 10.4103/jispcd.JISPCD_57_22. eCollection 2022 May-Jun.
Gingival overgrowth (GO) as a manifestation of calcium channel blockers (CCBs) was first introduced in the literature by Ramon in 1984. Since then, the use of CCBs as a treatment modality for hypertension has been recorded extensively in the literature for its association with GO.
The aim of our study is to evaluate histopathology, treatment, and follow-up for the cases detailed in various studies and also to highlight the protocol mentioned to identify these presentations.
A broad search was conducted from the period 1980 to 2021 using electronic databases PubMed Central, Scopus, Cochrane, and SciELO databases. About 293 articles were initially chosen. The articles further excluded did not fit the criteria for the study and eventually 50 articles which met the inclusion criteria were chosen as part of this literature review.
A comparative analysis was carried out regarding histopathology, treatment modalities, drug dosage, and duration to evaluate the differences in cases between 1980 and 2021. From the available studies, it was found that the histopathological and clinical findings were varied. Treatment strategies employed were different, though follow-ups in most cases were uniform.
CCBs and their relationship with GO have been widely reported in the literature. Dentists should approach this condition by taking appropriate medical and dental history and follow evidence-based treatment guidelines to provide more relevant and judicious management of this condition. Inter-disciplinary treatment approaches would provide better outcomes.
牙龈增生（GO）作为钙通道阻滞剂（CCB）的一种表现，于1984年由拉蒙首次在文献中提出。从那时起，CCB作为高血压治疗方式与GO的关联在文献中被广泛记载。
我们研究的目的是评估各项研究中详细描述病例的组织病理学、治疗及随访情况，并强调用于识别这些表现的方案。
利用电子数据库——美国国立医学图书馆的生物医学期刊数据库、Scopus数据库、Cochrane数据库以及科学电子图书馆在线数据库，对1980年至2021年期间进行了广泛检索。最初筛选出约293篇文章。进一步排除不符合研究标准的文章，最终选取50篇符合纳入标准的文章作为本综述的一部分。
对组织病理学、治疗方式、药物剂量及持续时间进行了对比分析，以评估1980年至2021年病例间的差异。从现有研究发现，组织病理学和临床发现各不相同。采用的治疗策略各异，不过大多数情况下随访是统一的。
CCB及其与GO的关系在文献中已有广泛报道。牙医应通过获取适当的医学和牙科病史来处理这种情况，并遵循循证治疗指南，以便对这种情况提供更相关且明智的管理。跨学科治疗方法将带来更好的结果。
