Lucas R M, Howell L P, Wall B A
J Periodontol. 1985 Apr;56(4):211-5. doi: 10.1902/jop.1985.56.4.211.
Gingival hyperplasia induced by nifedipine (Procardia), a calcium channel-blocking agent used as an anti-anginal drug, was studied. In recent months, the role of nifedipine in the etiology of gingival hyperplasia has attracted interest. The purpose of this study was to determine the causal relationship and compare nifedipine to other drug-induced (phenytoin) and nondrug-induced gingival hyperplasias. Histochemical studies revealed increased numbers of fibroblasts containing strongly sulfated mucopolysaccharides in the nifedipine- and phenytoin- (Dilantin) induced gingival hyperplasias as compared to the nondrug-induced cases. Numerous secretory granules were also noted in the fibroblast cytoplasm in the nifedipine-treated case studied by electron microscopy. These results imply that there is an increase in acid mucopolysaccharide production in the nifedipine- and phenytoin-induced gingival hyperplasias. The potential significance and comparisons of the drugs' effects at the cellular level are discussed.
对硝苯地平（心痛定）所致牙龈增生进行了研究，硝苯地平是一种用作抗心绞痛药物的钙通道阻滞剂。近几个月来，硝苯地平在牙龈增生病因学中的作用引起了关注。本研究的目的是确定因果关系，并将硝苯地平与其他药物（苯妥英）所致及非药物所致牙龈增生进行比较。组织化学研究显示，与非药物所致病例相比，硝苯地平及苯妥英（地仑丁）所致牙龈增生中含有强硫酸化粘多糖的成纤维细胞数量增加。通过电子显微镜研究的硝苯地平治疗病例中，成纤维细胞胞质内也可见大量分泌颗粒。这些结果表明，硝苯地平及苯妥英所致牙龈增生中酸性粘多糖的产生增加。讨论了这些药物在细胞水平作用的潜在意义及比较。
