Krunic A L, Cockerell C J, Truelson J, Taylor R S
Department of Dermatology, University of Illinois College of Medicine, Chicago, IL, USA.
Clin Exp Dermatol. 2006 Mar;31(2):242-4. doi: 10.1111/j.1365-2230.2005.02020.x.
Distant metastases in squamous cell carcinoma of the larynx have an incidence of 6.5-7.2%, and most commonly involve the lungs, liver and bone. Metastases to the skin are exceedingly rare, with only 30 cases reported in the literature. Skin metastases may represent the first clinical evidence of impending locoregional recurrence, suggest distant metastatic spread, or rarely, be the first sign of 'silent' laryngeal tumour. They are usually considered a poor prognostic sign and most often affect the supradiaphragmatic area, i.e. the head, neck, thorax or upper extremities. Infradiaphragmatic presentation of metastatic laryngeal squamous cell carcinoma is exceptional, with only four cases reported in the literature. Here we present another.
喉鳞状细胞癌远处转移的发生率为6.5%-7.2%，最常累及肺、肝和骨。皮肤转移极为罕见，文献中仅报道了30例。皮肤转移可能是即将发生的局部区域复发的首个临床证据，提示远处转移扩散，或很少情况下是“隐匿性”喉肿瘤的首个征象。它们通常被认为是预后不良的征象，最常累及膈上区域，即头部、颈部、胸部或上肢。喉鳞状细胞癌转移至膈下的情况极为罕见，文献中仅报道了4例。本文在此报告另外1例。
